Skip to main content
Featured Researchers

Dr Angelo Homayoun All

Associate Professor
Department of Chemistry
Faculty of Science

BACK
Dr Angelo Homayoun  All

Contact

About

The focus of Dr Angelo Homayoun All’s research is on nervous system injury, repair and regeneration. His laboratory has pioneered the monitoring and quantitative analysis of multi-channel somatosensory and motor-evoked potentials in order to assess the electrical integrity of the nervous system at various stages, both pre- and post-injury. His translational research projects involve hypothermia treatment as well as stem cell replacement therapy derived from human embryonic stem cells, human iPS cells, and direct conversion by trans-differentiation of human adult cells. These stem cells are also modified to induce overexpression of neurotrophic factors in order to modulate the lesion microenvironment and stimulate endogenous regenerative responses post-injury. 

 

A part of Dr All’s laboratory is also investigating the application of upconversion nanoparticles in conjunction with near infrared illumination systems for the neuromodulation applications both in vitro and in vivo. The goal is to develop a semi-invasive tool for stimulating or inhibiting, with spatio-temporal precision, neuropathways situated deep in the nervous system (the spinal cord, motor cortex, vagus nerve, etc) selectively. In addition, his laboratory is studying the adult central nervous system’s capabilities of adaptive changes enabling reorganisation and plasticity in spared neuropathways following neuro-trauma. In his projects, Dr All has also integrated different imaging techniques to monitor anatomical changes in contused spinal cord architectures at various time points enabling him to identify spared fibres (anatomically intact but non-functional neuropathways post-injury) and tracking the extent of secondary injury to determine the therapeutic benefits of the various treatment strategies.

 

Achievements

  • Engineering-Medicine Award (2015)
  • A*STAR – JST Japan Joint Program (2016-19)
  • NUS Ministry of Education - Academic Research Fund (2016-19)
  • National Medical Research Council NMRC CBRG NIG (2016-19)
  • NUS – National Research Fund (NRF - CRP) (2013-19)
  • National Medical Research Council (NMRC) - NUS (2013-19)
  • State of Maryland Stem Cell Research Fund (2013-17)
  • GSK Bioelectronics Innovation Challenge (2015)
  • NUHS CLINICIAN RESEARCH GRANT (2015)
  • NUS Ministry of Education - Academic Research Fund (2013-17)
  • NUS - SINAPSE Institute – SCI Research Fund (2012-20)
  • Maryland Stem Cell Research Fund – TEDCO (2009-13)
  • State of Maryland Stem Cell Research Fund TEDCO (2007-11)

 

Research Outputs

  • Liu, Xiaogang, Xiao Zeng, Shuo Chen, Adam Weitemier, Sanyang Han, Agata Blasiak, Ankshita Prasad, Kezhi Zheng, Zhigao Yi, Baiwen Luo, In-hong Yang, Nitish V. Thakor, Chou Chai Kah-leong Lim, Thomas J. Mchugh & Angelo H. All. “Visualization of intra‐neuronal motor protein transport through upconversion microscopy.” Angewandte Chemie International Edition 131.27 (2019): 9262-9268.
  • Liang, Liangliang, Daniel B. L. Teh, Ngoc-duy Dinh, Weiqiang Chen, Qiushui Chen, Yiming Wu, Srikanta Chowdhury, Akihiro Yamanaka, Tze-chien Sum, Chia-hung Chen, Nitish V. Thakor, Angelo H. All & Xiaogang Liu. “Upconversion amplification through dielectric superlensing modulation.” Nature Communications 10.1 (2019): 1-9.
  • All, Angelo H., Xiao Zeng, Daniel B. L. Teh, Zhigao Yi, Ankshita Prasad, Toru Ishizuka, Nitish V. Thakor, Yawo Hiromu & Xiaogang Liu. “Expanding the Toolbox of upconversion nanoparticles for in vivo optogenetics and neuromodulation.” Advanced Materials 31.41 (2019): 1803474.
  • Yi, Zhigao, Zichao Luo, Nicole D. Barth, Xianfu Meng, Hong Liu, Wenbo Bu, Angelo H. All, Marc Vendrell & Xiaogang Liu. “In Vivo Tumor Visualization through MRI Off‐On Switching of NaGdF4–CaCO3 Nanoconjugates.” Advanced Materials 31.37 (2019): 1901851.
  • Teh, Daniel B. L., Ankshita Prasad, Wenxuan Jiang, Nianchen Zhang, Yang Wu, Hyunsoo Yang, Sanyang Han, Zhigao Yi, Yanzhuang Yeo, Toru Ishizuka, Limsoon Wong, Nitish V. Thakor, Hiromu Yawo, Xiaogang Liu & Angelo H. All. “Driving Neurogenesis in Neural Stem Cells with High Sensitivity Optogenetics.” Neuromolecular Medicine 22.49 (2019): 1-11.
  • Chen, Qiushui, Jing Wu, Xiangyu Ou, Bolong Huang, Jawaher Almutlaq, Ayan A. Zhumekenov, Xinwei Guan, Sanyang Han, Liangliang Liang, Zhigao Yi, Juan Li, Xiaoji Xie, Yu Wang, Ying Li, Dianyuan Fan, Daniel B. L. Teh, Angelo H. All, Omar F. Mohammed, Osman M. Bakr, Tom Wu, Marco Bettinelli, Huanghao Yang, Wei Huang & Xiaogang Liu. “All-inorganic perovskite nanocrystal scintillators.” Nature 561.7721 (2018): 88-93.
  • Han, Sanyang, Animesh Samanta, Xiaoji Xie, Ling Huang, Juanjuan Peng, Sung Jin Park, Daniel B. L. Teh, Yongdoo Choi, Young-tae Chang, Angelo H. All, Yanmei Yang, Bengang Xing & Xiaogang Liu. “Gold and hairpin DNA functionalization of upconversion nanocrystals for imaging and in vivo drug delivery.” Advanced Materials 29.18 (2017): 1700244.
  • Liu, Xiaowang, Yu Wang, Xiyan Li, Zhigao Yi, Renren Deng, Liangliang Liang, Xiaoji Xie, Daniel B. L. Teh, Shuyan Song, Dianyuan Fan, Angelo H. All, Hongjie Zhang, Ling Huang & Xiaogang Liu. “Binary temporal upconversion codes of Mn 2+-activated nanoparticles for multilevel anti-counterfeiting.” Nature Communications 8.1 (2017): 1-7.
  • Peng, Juanjuan, Animesh Samanta, Xiao Zeng, Sanyang Han, Lu Wang, Dongdong Su, Daniel B. L. Teh, Nam-young Kang, Sung-jin Park, Angelo H. All, Wenxuan Jiang, Lin Yuan, Xiaogang Liu & Young-tae Chang. “Real‐Time In Vivo Hepatotoxicity Monitoring through Chromophore‐Conjugated Photon‐Upconverting Nanoprobes.” Angewandte Chemie International Edition 56.15 (2017): 4165-4169.
  • Prasad, Ankshita, Daniel B. L. Teh, Agata Blasiak, Chou Chai, Yang Wu, Payam M. Gharibani, In-hong Yang, Thang T. Phan, Kah-leong Lim, Hyunsoo Yang, Xiaogang Liu & Angello H. All. “Static magnetic field stimulation enhances oligodendrocyte differentiation and secretion of neurotrophic factors.” Scientific Reports 7.1 (2017): 1-12.
  • Daniel B. L. Teh, Ankshita Prasad, Wenxuan Jiang, Mohd. Zacky Ariffin, Sanjay Khanna, Abha Belorkar, Limsoon Wong, Xiaogang Liu & Angelo H. All. “Transcriptome analysis reveals neuroprotective aspects of human reactive astrocytes induced by interleukin 1β.” Scientific Reports 7.1 (2017): 1-12.
  • Lee, Hae-ung, Agata Blasiak, Devansh R. Agrawal, Daniel B. L. Teh, Nitish V. Thakor, Angelo H. All, John S. Ho & In-hong Yang. “Subcellular electrical stimulation of neurons enhances the myelination of axons by oligodendrocytes.” PloS ONE 12.7 (2017): e0179642.
  • Mir, Hasan, Hasan Al-Nashash, Jukka Kortelainen & Angelo H. All. “Novel Modeling of somatosensory evoked potentials for the assessment of spinal cord injury.” IEEE Transactions on Biomedical Engineering 65.3 (2017): 511-520.
  • Teh, Daniel B. L., Soo-min Chua, Ankshita Prasad, Ioannis Kakkos, Wenxuan Jiang, Yue Mu, Xiaogang Liu & Angelo H. All. “Neuroprotective assessment of prolonged local hypothermia post contusive spinal cord injury in rodent model.” The Spine Journal 18.3 (2017): 507-514.
  • Prasad, Ankshita, Janani Manivannan, Daniel B. L. Teh, Soo-min Chua, Payam M. Gharibani & Angelo H. All. “A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation.” Regenerative Medicine 11.2 (2016): 181-191.
  • Liang, Liangliang, Xiaoji Xie, Daniel B. L. Teh, Angelo H. All, Ling Huang & Xiaogang Liu. “Designing Upconversion Nanocrystals Capable of 745 nm Sensitization and 803 nm Emission for Deep‐Tissue Imaging.” Chemistry–A European Journal 22.31 (2016): 10801-10807.
  • Kadkhodaei, Mahsa, Shadrokh Samavi, Nader Karimi, Hoda Mohaghegh, S. M. Reza Soroushmehr, Angelo H. All, Kevin R. Ward & Kayvan Najarian. “Automatic segmentation of multimodal brain tumor images based on classification of super-voxels.” Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society (2016).
  • Xiang, Zhuolin, Shih-cheng Yen, Chengkuo Lee, Sanghoon Lee, Nitish V. Thakor, Amitabha Lahiri, Faith A. Bazley, Ashwati Vipin, Ignacio D. Martinez, Angelo H. All & Yen-xian Peh. “Flexible neural strip electrodes, flexible neural ribbon electrodes and compartment based embedded nerve tissue electrode interfaces for peripheral nerves.” United States Patent Application 15.043 (2016): 688.
  • Prasad, Ankshita, Daniel B. L. Teh, Fathima Rifkhana Shah Jahan, Janani Manivannan, Soo-min Chua & Angelo H. All. “Direct conversion through trans-differentiation: efficacy and safety.” Stem Cells and Development 26.3 (2016): 154-165.
  • Vipin, Ashwati, Xinyuan Thow, Hasan Mir, Jukka Kortelainen, Janani Manivannan, Hasan Al-Nashash & Angelo H. All. “Natural progression of spinal cord transection injury and reorganization of neural pathways.” Journal of Neurotrauma 33.24 (2016): 2191-2201.
  • Väyrynen, Eero, Kai Noponen, Ashwati Vipin, Xinyuan Thow, Hasan Al-Nashash, Jukka Kortelainen & Angelo H. All. “Automatic parametrization of somatosensory evoked potentials with chirp modeling.” IEEE Transactions on Neural Systems and Rehabilitation Engineering 24.9 (2016): 1-1.
  • All, Angelo H., Payam Gharibani, Siddharth Gupta, Faith A. Bazley, Nikta Pashai, Bin-kuan Chou, Sandeep Shah, Linda M. S. Resar, Linzhao Cheng, John D. Gearhart & Candace L. Kerr. “Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.” PLoS ONE 10.1 (2015).
  • Bazley, Faith A., Cyndi F. Liu, Xuan Yuan, Haiping Hao, Angelo H. All, Alejandro De Los Angeles, Elias T. Zambidis, Hohn D. Gearhart & Candace L. Kerr. “Direct reprogramming of human primordial germ cells into induced pluripotent stem cells: efficient generation of genetically engineered germ cells.” Stem Cells and Development 24.22 (2015): 2634-2648.
  • Kortelainen, Jukka, Hasan Al-Nashash, Ashwati Vipin, Xinyuan Thow & Angelo H. All. “The effect of anaesthesia on somatosensory evoked potential measurement in a rat model.” Laboratory Animals 50.1 (2015): 63-66.
  • Vipin, Ashwati, Jukka Kortelainen, Hasan Al-Nashash, Soo-min Chua, Xinyuan Thow, Janani Manivannan, Astrid, Nitish V. Thakor, Candace L. Kerr & Angelo H. All. “Prolonged local hypothermia has no long-term adverse effect on the spinal cord.” Therapeutic Hypothermia and Temperature Management 5.3 (2015): 152-162.
  • Bazley, Faith A., Anil Maybhate, Chuen-seng Tan, Nitish V. Thakor, Candace L. Kerr & Angelo H. All. “Enhancement of bilateral cortical somatosensory evoked potentials to intact forelimb stimulation following thoracic contusion spinal cord injury in rats.” IEEE Transactions on Neural Systems and Rehabilitation Engineering 22.5 (2014).
  • Bazley, Faith A., Nikta Pashai, Candace L. Kerr & Angelo H. All. “The effects of local and general hypothermia on temperature profiles of the central nervous system following spinal cord injury in rats.” Therapeutic Hypothermia and Temperature Management 4.3 (2014): 115-124.
  • Kortelainen, Jukka, Ashwati Vipin, Xinyuan Thow, Hasan Mir, Nitish V. Thakor, Hasan Al-Nashash & Angelo H. All. “Effect of isoflurane on somatosensory evoked potentials in a rat model.” Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society (2014).
  • Bazley, Faith A., Nikta Pashai, Candace Kerr, Nitish V. Thakor & Angelo H. All. “A simple and effective semi-invasive method for inducing local hypothermia in rat spinal cord.” Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society (2013): 6321-6324.
  • All, Angelo H., Faith A. Bazley, Siddharth Gupta, Nikta Pashai, Charles Hu, Amir Pourmorteza & Candace L. Kerr. “Human embryonic stem cell-derived oligodendrocyte progenitors aid in functional recovery of sensory pathways following contusive spinal cord injury.” PloS ONE 7.10 (2012): e47645.
  • Maybhate, Anil, Charles Hu, Faith A. Bazley, Qilu Yu, Nitish V. Thakor, Candace L. Kerr & Angelo H. All. “Potential long term benefits of acute hypothermia after spinal cord injury: assessments with somatosensory evoked potentials.” Critical Care Medicine 40.2 (2012): 573.
  • Bazley, Faith A., Charles Hu, Anil Maybhate, Amir Pourmorteza, Nikta Pashai, Nitish V. Thakor, Candace L. Kerr & Angelo H. All. “Electrophysiological evaluation of sensory and motor pathways after incomplete unilateral spinal cord contusion.” Journal of Neurosurgery 16.4 (2012): 414-423.
  • Pashai, Nikta, Haiping Hao, Angelo H. All, Siddharth Gupta, Raghothama Chaerkady, Alejandro De Los Angeles, John D. Gearhart & Candace L. Kerr. “Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells.” PLoS ONE 7.6 (2012).
  • Bazley, Faith A., Amir Pourmorteza, Siddharth Gupta, Nikta Pashai, Candace L. Kerr & Angelo H. All. “DTI for assessing axonal integrity after contusive spinal cord injury and transplantation of oligodendrocyte progenitor cells.” Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society (2012): 82-85.
  • Walczak, Piotr, Angelo H. All, Nidhi Rumpal, Michael Gorelik, Heechul Kim, Anil Maybhate, Gracee Agrawal, James T. Campanelli, Assaf Gilad, Douglas Kerr & Jeff W. M. Bulte. “Human glial‐restricted progenitors survive, proliferate, and preserve electrophysiological function in rats with focal inflammatory spinal cord demyelination.” Glia 59.3 (2011): 499-510.
  • Chaerkady, Raghothama, Brian Letzen, Santosh Renuse, Nandini A. Sahasrabuddhe, Praveen Kumar, Angelo H. All, Nitish V. Thakor, Bernard Delanghe, John D. Gearhart, Akhilesh Pandey & Candace L. Kerr. “Quantitative temporal proteomic analysis of human embryonic stem cell differentiation into oligodendrocyte progenitor cells.” Proteomics 11.20 (2011): 4007-4020.
  • Bazley, Faith A., Angelo H. All, Nitish V. Thakor & Anil Maybhate. “Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats.” Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society (2011): 2005-2008
  • Mir, Hasan, Hasan Al-Nashash, Douglas Kerr, Angelo H. All & Nitish V. Thakor. “Spinal Cord Injury Evaluation Using Morphological Difference of Somatosensory Evoked Potentials.” 2011 5th International Conference on Bioinformatics and Biomedical Engineering (2011).
  • Letzen, Brian S., Cyndi Liu, Nitish V. Thakor, John D. Gearhart, Angelo H. All, Candace L. Kerr. “MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells.” PloS ONE 5.5 (2010).
  • Kerr, Candace L., Brian S. Letzen, Christine M. Hill, Gracee Agrawal, Nitish V. Thakor, Jared L. Sterneckert, John D. Gearhart & Angelo H. All. “Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury.” International Journal of Neuroscience 120.4 (2010): 305-313.
  • Agrawal, Gracee, Candace L. Kerr, Nitish V. Thakor & Angelo H. All. “Characterization of graded multicenter animal spinal cord injury study contusion spinal cord injury using somatosensory-evoked potentials.” Spine 35.11 (2010): 1122-1127.
  • Agrawal, Gracee, David Sherman, Anil Maybhate, Michael Gorelik, Douglas A. Kerr, Nitish V. Thakor & Angelo H. All. “Slope analysis of somatosensory evoked potentials in spinal cord injury for detecting contusion injury and focal demyelination.” Journal of Clinical Neuroscience 17.9 (2010): 1159-1164.
  • Iyer, Shrivats M., Anil Maybhate, Alessandro Presacco & Angelo H. All. “Multi-limb acquisition of motor evoked potentials and its application in spinal cord injury.” Journal of Neuroscience Methods 193.2 (2010): 210-216.
  • All, Angelo H., Gracee Agrawal, Piotr Walczak, Anil Maybhate, Jeff W. M. Bulte & Douglas A. Kerr. “Evoked potential and behavioral outcomes for experimental autoimmune encephalomyelitis in Lewis rats.” Neurological Sciences 31.5 (2010): 595-601.
  • Agrawal, Gracee, Candace L. Kerr, Nitish V. Thakor & Angelo H. All. “Characterization of graded MASCIS contusion spinal cord injury using somatosensory evoked potentials.” Spine 35.11 (2010): 1122-1127.
  • Mir, Hasan, Hasan Al-Nashash, Douglas Kerr, Nitish V. Thakor & Angelo H. All. “Histogram based quantification of spinal cord injury level using somatosensory evoked potentials.” Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society (2010): 4942-4945.
  • Sherman, David L., Varalakshmi Wuyyuru, M. Jason Brooke, Hexin Zhang, Jehuda P. Sepkuty, Nitish V. Thakor, A. Natarajan & Angelo H. All. “Spinal cord integrity monitoring by adaptive coherence measurement.” Journal of Neuroscience Methods 193.1 (2010): 90-99.
  • Mir, Hasan, Hasan Al-Nashash, Angelo H. All & Nitish V. Thakor. “Quantification of spinal cord injury level using somatosensory evoked potentials.” 2010 4th International Conference on Bioinformatics and Biomedical Engineering (2010).
  • All, Angelo H. “Addressing the Inadequacies of the Current Healthcare Model with a Universal Healthcare System in the United States.” World Medical & Health Policy 2.1 (2010): 363.
  • Agrawal, Gracee, Nitish V. Thakor & Angelo H. All. “Evoked potential versus behavior to detect minor insult to the spinal cord in a rat model.” Journal of Clinical Neuroscience 16.8 (2009): 1052-1055.
  • Al-Nashash, Hasan, Noreen A. Fatoo, Nabil N. Mirza, Ahmed M. R. Rabi, Gracee Agrawal, Nitish V. Thakor & Angelo H. All. “Spinal cord injury detection and monitoring using spectral coherence.” IEEE Transactions on Biomedical Engineering 56.8 (2009): 1971-1979.
  • All, Angelo H., Piotr Walczak, Gracee Agrawal, Michael Gorelik, Christopher Lee, Nitish V. Thakor, Jeff W. M. Bulte & Douglas Kerr. “Effect of MOG sensitization on somatosensory evoked potential in Lewis rats.” Journal of the Neurological Sciences 284.1-2 (2009): 81-89.
  • Agrawal, Gracee, Shrivats M. Iyer & Angelo H. All. “A comparative study of recording procedures for motor evoked potential signals.” Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society (2009): 2086-2089.
  • Agrawal, Gracee, D. L. Sherman, Piotr Walczak, Jeff W. M. Bulte, Nitish V. Thakor, Douglas A Kerr & Angelo H. All. “Shape analysis of Somatosensory Evoked Potentials to detect a focal spinal cord lesion.” Bioengineering Conference, 2009 IEEE 35th Annual Northeast (2009): 1-2.
  • Agrawal, Gracee, David Sherman, Nitish V. Thakor & Angelo H. All. “A novel shape analysis technique for somatosensory evoked potentials.” Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society (2008): 4688-4691.
  • Murari, Kartikeya, Nanxi Li, Abhishek Rege, Xiaodong Jia, Angelo H. All & Nitish V. Thakor. “Contrast-enhanced imaging of cerebral vasculature with laser speckle.” Applied Optics 46.22 (2007): 5340-5346.
  • Fatoo, Noreen, Nabil Mirza, Rabi Ahmad, Hasan Al-Nashash, Homayoun Naeini & Nitish V. Thakor. “Detection and assessment of spinal cord injury using spectral coherence.” Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society (2007): 1426-1429.
  • All, Angelo H., Noreen A. Fatoo, Nabil N. Mirza, Rabi I. Ahmed, Hasan Al-Nashash & Nitish V. Thakor. “Using spectral coherence for the detection and monitoring of spinal cord injury.” 4th IEEE GCC Industrial Electrical Electronics Conference (2007).
  • Ye, Deliang, Homayoun Mozaffari‐Naeini, Carl Busart & Nitish V. Thakor. “MEMSurgery: an integrated test‐bed for vascular surgery.” The International Journal of Medical Robotics and Computer Assisted Surgery 1.3 (2005): 21-30.
  • Sauer, Christian M., Damian H. Tomlin, Homayoun M. Naeini, Oleg Gerovichev & Nitish V. Thakor. “Real-time measurement of blood vessel occlusion during microsurgery.” Computer Aided Surgery 7.6 (2002): 364-370.
  • Gerovichev, O., H. Mozaffari Naeini, D. L. Sherman, Feras Al Hatib, S. Venkatesha, Romergryko G. Geocadin, Daniel F. Hanley & Nitish V. Thakor. “Detection of brain herniation with spectral coherence analysis of somatosensory evoked potentials.” Engineering in Medicine and Biology. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference (2002).