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Professor Nai-ki Mak

Professor
Department of Biology
Faculty of Science

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Professor  Nai-ki Mak

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The recent work of Professor Mak Nai-ki focuses on (1) understanding the role of Wnt signalling in the pathogenesis of nasopharyngeal carcinoma, and (2) the development of drugs against EBV-associated malignancies, particularly on nasopharyngeal carcinoma.

Highlights

Publications

  • Jiang, Lijun, Hong-lok Lung, Tao Huang, Rongfeng Lan, Shuai Zha, Lai-sheung Chan, Waygen Thor, Tik-hung Tsoi, Ho-fai Chau, Cecilia Boreströmg, Steven L. Cobb, Sai-wah Tsao, Zhao-xiang Bian, Ga-lai Law, Wing-tak Wong, William Chi-shing Tai, Wai-yin Chau, Yujun Du, Lucas Hao-xi Tang, Alan Kwok-shing Chiang, Jaap M. Middeldorp, Kwok-wai Lo, Nai-ki Mak, Nicholas J. Long & Ka-leung Wong. “Reactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function.” PNAS 116.52 (2019): 26614-26624. www.pnas.org/cgi/doi/10.1073/pnas.1915372116

 

  • Chen, Luo, Lai-sheung Chan, Hong-lok Lung, Timothy Tak-chun Yip, Roger Kai-cheong Ngan, Jonathan Woon-chung Wong, Kwok-wai Lo, Wai-tong Ng, Anne Wing-mui Lee, George Sai-wah Tsao, Maria Li Lung & Nai-ki Mak. “Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/ Wnt inhibitory factor 1 (WIF1) axis.” Phytomedicine 63 (2019). https://doi.org/10.1016/j.phymed.2019.153058

 

  • Chan, Lai-sheung, On-ying Man, Hoi-hin Kwok, Luo Chen, King-chi Chan, Hong-lok Lung, Roger Kai-cheong Ngan, Ricky Ngok-shun Wong, Kwok-wai Lo, Anne Wing-mui Lee, George Sai-wah Tsao, Michael Kahn, Maria Li Lung & Nai-ki Mak. “The Wnt modulator ICG-001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR-150/CD44 axis.” International Journal of Oncology 54.3 (2018). DOI: 10.3892/ijo.2018.4664.

 

  • Jiang, Lijun, Rongfeng Lan, Tao Huang, Chi-fai Chan, Hongguang Li, Sam Lear, Jingyi Zong, Wing-yan Wong, Magnolia Muk-lan Lee, Brandon Dow Chan, Wai-lun Chan, Wai-sum Lo, Nai-ki Mak, Maria Li Lung, Hong-lok Lung, Sai-wah Tsao, Graham S. Taylor, Zhao-xiang Bian, William C. S. Tai, Ga-lai Law, Wing-tak Wong, Steven L. Cobb & Ka-leung Wong. “EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein–Barr virus.”  Nature Biomedical Engineering 1.4 (2017). DOI: 10.1038/s41551-017-0042.