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Dr Wei-shen Aik

Assistant Professor
Department of Chemistry
Faculty of Science

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Dr Wei-shen Aik

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About

Dr Aik Wei-shen is interested in studying protein-nucleic acid complexes in various contexts, such as RNA metabolism, viral replication and cancer. He also aspires to be innovative in designing therapies using structures of protein/nucleic acid complexes as guides. The core technique is macromolecular X-ray crystallography. Dr Aik is also interested in using other structural biology tools such as cryo-electron microscopy to obtain the structural information of macromolecules. He takes advantage of powerful techniques in chemistry to detect, analyse and probe biomolecules. Examples of techniques frequently used are mass spectrometry and liquid chromatography. He also incorporates molecular biology techniques into his research.

 

Achievements

  • RGC Early Career Scheme (2019-20)

 

Research Outputs

  • Sun, Yadong, Yixiao Zhang, Wei-shen Aik, Xiaocui Yang, William F. Marzluff, Thomas Walz, Zbigniew Dominski & Tong Liang. “Structure of an active human histone pre-mRNA 3’-end processing machinery.” Science 367.6478 (2020): 700-703. https://science.sciencemag.org/content/367/6478/700
  • Bucholc, Katarzyna, Wei-shen Aik, Xiaocui Yang, Kaituo Wang, Z. Hong Zhou, Michał Dadlez, William F. Marzluff, Tong Liang & Zbigniew Dominski. “Composition and processing activity of a semi-recombinant holo U7 snRNP.” Nucleic Acids Research 48.3 (2020): 1508-1530. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz1148/5670844
  • Aik, Wei-shen, Min-han Lin, Dazhi Tan, Ashutosh Tripathy, William F. Marzluff, Zbigniew Dominski, Chi-yuan Chou & Tong Liang. “The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing.” PLoS ONE 12.10 (2017), art. no. e0186034. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186034
  • Horita, Shoichiro, John S. Scotti, Cyrille Thinnes, Yousef S. Mottaghi-Taromsari, Armin Thalhammer, Wei Ge, Wei-shen Aik, Christoph Loenarz, Christopher J. Schofield & Michael A. McDonough. “Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases.” Structure 23.4 (2015): 639-652. http://www.sciencedirect.com/science/article/pii/S0969212615000386
  • McMurray, Fiona, Marina Demetriades, Wei-shen Aik, Myrte Merkestein, Holger Kramer, Daniel S. Andrew, Cheryl L. Scudamore, Tertius A. Hough, Sara Wells, Frances M. Ashcroft, Michael A. McDonough, Christopher J. Schofield & Roger D. Cox. “Pharmacological inhibition of FTO.” PLoS ONE 10.4 (2015): e0121829. http://dx.plos.org/10.1371/journal.pone.0121829
  • Aik, Wei-shen, Rasheduzzaman Chowdhury, Ian J. Clifton, Richard J. Hopkinson, Thomas Leissing, Michael A. McDonough, Radosław Nowak, Christopher J. Schofield & Louise J. Walport. “Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes.” RSC Metallobiology 3 (2015): 59-94. https://pubs.rsc.org/--/content/chapter/bk9781849739504-00059/978-1-84973-950-4
  • Scotti, John S., Ivanhoe K. H. Leung, Wei Ge, Michael A. Bentley, Jordi Paps, Holger B. Kramer, Joongoo Lee, Wei-shen Aik, Hwanho Choi, Steinar M. Paulsen, Lesley A. H. Bowman, Nikita D. Loik, Shoichiro Horita, Chia-hua Ho, Nadia J. Kershaw, Christoph M. Tang, Timothy D. W. Claridge, Gail M. Preston, Michael A. McDonough & Christopher J. Schofield. “Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.” Proceedings of the National Academy of Sciences of the United States of America 111.37 (2014): 13331-13336. http://www.pnas.org/content/111/37/13331.short
  • Xu, Chao, Ke Liu, Wolfram Tempel, Marina Demetriades, Wei-shen Aik, Christopher J. Schofield & Jinrong Min. “Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.” Journal of Biological Chemistry 289.25 (2014): 17299-17311. http://www.jbc.org/content/early/2014/04/28/jbc.M114.550350.1.short
  • Aik, Wei-shen, John S. Scotti, Hwanho Choi, Lingzhi Gong, Marina Demetriades, Christopher J. Schofield, Michael A. McDonough. “Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.” Nucleic Acids Research 42.7 (2014): 4741-4754. http://nar.oxfordjournals.org/content/42/7/4741.short
  • Brem, Jürgen, Sander S. van Berkel, Wei-shen Aik, Anna Maria Rydzik, Matthew B. Avison, Ilaria Pettinati, Klaus-Daniel Umland, Akane Kawamura, James Spencer, Timothy D. W. Claridge, Michael A. McDonough & Christopher J. Schofield. “Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β 2-lactamase inhibition.” Nature Chemistry 6.12 (2014): 1084-1090. http://www.nature.com/nchem/journal/v6/n12/abs/nchem.2110.html
  • Hopkinson, Richard J., Anthony Tumber, Clarence Yapp, Rasheduzzaman Chowdhury, Wei-shen Aik, Ka-hing Che, Xuan Shirley Li, Jan B. L. Kristensen, Oliver N. F. King, Mun Chiang Chan, Kar Kheng Yeoh, Hwanho Choi, Louise J. Walport, Cyrille C. Thinnes, Jacob T. Bush, Clarisse Lejeune, Anna M. Rydzik, Nathan R. Rose, Eleanor A. Bagg, Michael A. McDonough, Tobias J. Krojer, Wyatt W. Yue, Stanley S. Ng, Lars Olsen, Paul E. Brennan, Udo Oppermann, Susanne Müller, Robert J. Klose, Peter J. Ratcliffe, Christopher J. Schofield & Akane Kawamura. “5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation.” Chemical Science 4.8 (2013): 3110-3117. http://pubs.rsc.org/en/Content/ArticleLanding/2013/SC/c3sc51122g#!divAbstract
  • Aik, Wei-shen, Marina Demetriades, Muhammad K. K. Hamdan, Eleanor A. L. Bagg, Kar Kheng Yeoh, Clarisse Lejeune, Zhihong Zhang, Michael A. McDonough & Christopher J. Schofield. “Structural basis for inhibition of the fat mass and obesity associated protein (FTO).” Journal of Medicinal Chemistry 56.9 (2013): 3680-3688. http://pubs.acs.org/doi/abs/10.1021/jm400193d
  • Aik, Wei-shen, Michael A. McDonough, Armin Thalhammer, Rashed Chowdhury & Christopher J. Schofield. “Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases.” Current Opinion in Structural Biology 22.6 (2012): 691-700. http://www.sciencedirect.com/science/article/pii/S0959440X12001595
  • Woon, Esther C. Y., Marina Demetriades, Eleanor A. L. Bagg, Wei-shen Aik, Svetlana M. Krylova, Jerome H. Y. Ma, Munchiang Chan, Louise J. Walport, David W. Wegman, Kevin N. Dack, Michael A. McDonough, Sergey N. Krylov & Christopher J. Schofield. “Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.” Journal of Medicinal Chemistry 55.5 (2012): 2173-2184. http://pubs.acs.org/doi/abs/10.1021/jm201417e
  • Thalhammer, Armin, Wei-shen Aik, Eleanor A. L. Bagg & Christopher J. Schofield. “The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets.” Drug Discovery Today: Therapeutic Strategies, 9.2-3 (2012): e91-e100. http://www.sciencedirect.com/science/article/pii/S1740677312000083