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计算医药学实验室

实验室基於浸大中医药学院和理学院（生物系、化学系、数学系和计算机系）的协力合作，创造一个在香港乃至中国最具创新的从中医药出发的现代诊疗和新药研发基地。实验室将在生物医学和化学的基础上，结合数据科学、资讯科学等先进技术，在浸大打造出一套世界级最完整的现代中医药数据资产，成为全球基於中医药的现代诊疗和新药研发的最权威知识库。浸大在此研究领域有著非常卓越、扎实的研究基础。我们将在现有基础上，聘请科研领军人才，力争於三年内，实现包括基於现代分子生物学的「本草纲目新编」中医知识库系统和中药复方协同机制等重大科研成果，同时於大湾区创建第一流的现代中药新药创新产业基地，完善从科研到产业的转化流程，为浸大创造具有国际领先水准的创新产业发展环境。

 

实验室成员

按此浏览实验室成员名单

 

实验室遴选委员会

联席主席：

 

  • 吕爱平教授 (中医药学院院长)
  • 刘际明教授 (理学院院长)

 

成员：

 

  • 卞兆祥教授 (中医药学)
  • 阮邦志教授 (计算机科学)
  • 翁建霖教授  (生物学)
  • 张宏杰教授 (中医药学)
  • 张世平博士 (中医药学)

 

项目：

  1. “New Drug Discovery for Aging-associated Neurodegenerative Disorders-Parkinson's Disease”, PI: Prof. Min Li (SCM), Co-Is: Dr. Allen Cheung (BIOL), Dr. Edmond Ma (CHEM), Dr. Ken Leung (CHEM), Dr. King Ho Cheung (SCM), Dr. Chuanbin Yang (External), Dr. Juxian Song (External)
  2. “Detecting the Tipping Points from Inflammation to Tumorigenesis using a Multi-level Network Modeling Approach”, PI: Dr. William Cheung (COMP), Co-Is: Prof. Aiping Lyu (SCM), Prof. Jiming Liu (COMP), Dr. Liang Lan (COMP), Dr. Lu Zhang (COMP), Dr. Daogang Guang (External)
  3. “Specific Differentiation of Dopamine Neurons with Minimal Usage of Growth Factors to Develop Cell Replacement Therapy of Parkinson's Disease”, PI: Prof. Ken Yung (BIOL), Co-Is: Dr. Zhifeng Huang (PHYS), Dr. Stephen Sze (BIOL)
  4. “From Early Detection, Diagnostics to Therapeutics of Alzheimer’s Disease”, PI: Prof. Ricky M. S. Wong (CHEM), Co-Is: Dr. Hung Wing Li (CHEM), Prof. Min Li (SCM), Dr. Ashok Iyaswamy (SCM)
  5. “A High-resolution Global Metagenome Catalog from Uncultured Human Gut Microbiota”, PI: Dr. Lu Zhang (COMP), Co-Is: Prof. Zhaoxiang Bian (SCM), Prof. Xiaodong Fang (External)
  6.  “Chinese Herbal Drug Interaction”, PI: Prof. Zhaoxiang Bian (SCM), Co-I: Prof. Pong Chi Yuen (COMP)
  7.  “Research and development of triptolide-aptamer drug”, PI: Prof. Aiping Lyu (SCM)
  8. “Toward Targeted Therapy in Advanced Pancreatic Cancer: A Smart Triptolide-Nucleolin Aptamer Conjugate”, PI: Prof. Aiping Lyu (SCM)
  9. “Does aberrantly overexpressed CKIP-1 suppress osteoblast-mediated articular bone repair”, PI: Prof. Aiping Lyu (SCM), Co-Is: Dr. Xiaojuan He (External), Prof. Ge Zhang (SCM), Prof. Lingqiang Zhang (External)
  10. “Molecular mechanisms of obesity with Chinese medicine pattern of phlegm-dampness and its changes on hypertension”, PI: Prof. Aiping Lyu (SCM), Co-Is: Dr. Fangfei Li (SCM), Dr. Biao Liu (External), Dr. Bing He (External), Dr. Chao Liang (SCM), Dr. Jin Liu (SCM)
  11. “Onward an emerging paradigm of network medicine: An innovative platform to combinational herbs/compounds-based drug discovery for complex diseases”, PI: Prof. Aiping Lyu (SCM)
  12. “From precision medicine to drug discovery: osteoblast-specific inhibition of Smurf1 activity promotes bone formation in distinctive rats with age-related osteoporosis”, PI: Prof. Ge Zhang (SCM), Co-I: Dr. Chao Liang (SCM)
  13. “Functional Role of Plekho1 within osteoblast in regulating BMP signaling and bone formation during age-related osteoporosis development in both genders: from molecular mechanism to translational therapeutics”, PI: Prof. Ge Zhang (SCM), Co-I: Dr. Baoting Zhang (External)
  14. “Targeting sclerostin to reverse established osteoporosis: Aptamer characterization and evaluation for drug discovery”, PI: Prof. Ge Zhang (SCM), Co-Is: Dr. Chao Liang (SCM), Dr. Yuanyuan Yu (SCM)
  15. “To elucidate the anti-ebola potency of the active leads discovered based on the diversified plants in Lingnan region of China”, PI: Prof. Hongjie Zhang (SCM), Co-Is: Prof. Zhongzhen Zhao (SCM), Dr. Hailong Zhu (SCM)
  16. “Ent-kaurene analogs for control of colorectal carcinoma progression and metastasis”, PI: Prof. Hongjie Zhang (SCM), Co-Is: Dr. Zhizhan Gu (SCM), Prof. Zhongzhen Zhao (SCM)
  17. “Functional analysis of Corynoxine B in promoting autophagy and protecting neurons”, PI: Prof. Min Li (SCM), Co-I: Prof. Long Ma (External)
  18. “Understanding the molecular mechanisms of Corynoxine B in promoting autophagy and neuroprotection: Targeting HMGB1-Beclin 1 interaction”, PI: Prof. Min Li (SCM), Co-Is: Prof. Zhenyu Yue (External), Prof. Yanxiang Zhao (External)
  19. “Study of a novel TFEB activator on attenuating Tau pathology in Alzheimer’s disease”, PI: Prof. Min Li (SCM), Co-Is: Dr. Juxian Song (External), Prof. Joan Zhong Zuo (External)
  20. “Electrophysiological Characterization of the Two-Pore Channel 2”, PI: Dr. King Ho Cheung (SCM)
  21.  “基於大数据和人工智能的中医药知识体系分析及自动化药方生成及推荐”, PI: Prof. Lei Han Tang (PHYS), Co-Is: Prof. Aiping Lyu (SCM), Dr. Liang Tian (PHYS)
  22. “Joint Embedding of Sequential Data and Knowledge Graphs with application to Predictive Analytics in Healthcare”, PI: Dr. William Cheung (COMP), Co-Is: Dr. Benjamin Chin Ming Fung (External), Dr. Jonathan Amias Poon (External)
  23. “A Temporal Tensor Factorization Framework for Phenotyping and Dynamic Patient Representation Learning Using Multi-Modal EHR Data”, PI: Dr. William Cheung (COMP), Co-Is: Dr. Benjamin Chin Ming Fung (External), Dr. Jonathan Amias Poon (External)