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李敏教授

中医药学院副院长(教学)、教学科研部教授
高志明伉俪柏金逊症研究中心主任

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李敏教授

联络

简历

李敏教授，医学博士。为中医内科学、中药神经药理学、中医药治疗脑神经退行性疾病专家。目前担任香港浸会大学中医药学院副院长(教学)、中医与生物医学双学位课程主任和高智明伉俪柏金逊症研究中心主任。李教授1985年本科毕业于河南中医药大学，1988年硕士毕业于广州中医药大学，2001年在日本东海大学医学院获得医学博士。李教授主要从事神经系统退行性疾病包括柏金逊症和阿氏海默症的中医临床治疗、中药药理研究与新药研发工作。李教授的研究团队先后开展了中药复方治疗帕金森病、阿氏海默症的随机对照双盲的临床研究，从中药中筛选小分子天然自噬诱导剂治疗神经退行性疾病的分子作用机制及治疗脑神经退行性疾病的中药新药研发工作。

 

研究领域：

 

基础研究：

  • 神经细胞自噬/溶酶体功能异常在老年神经退行性疾病（包括柏金逊症、老年痴呆症）中的发病机制研究；
  • 中药复方及中药小分子化合物保护神经细胞的药效、作用机制及分子靶点研究；
  • 神经退行性疾病相关的代谢组学、蛋白组学的研究。

 

临床研究：

中药复方对柏金逊症和阿氏海默症的临床疗效与安全性评价研究。

 

新药研发：

从中药复方及中药小分子化合物研发治疗或预防老年神经退行性疾病（帕金森病和阿氏海默症）的中药新药和中药保健品。

 

 

主持的科研项目 (最近三年)

 

  • Evaluating the anti-Alzheimer’s disease efficacy of Caudatin, isolated from Chinese medicine herb Qingyangshen, on AD mice model (HMRF 17182541, PI)
  • Neuroprotective Effect of Chinese medicine NeuroDefend in Improving Memory Dysfunction and Alleviating AD Pathology (GDSSIL 84-506/2019, PI)
  • Study of Chinese Medicine Protopine on Attenuating Tau Pathology in Alzheimer's Disease: The Roles of Histone Deacetylase 6 (GRF/HKBU12100618, PI)
  • New Drug Discovery for Aging-associated Neurodegenerative Disorders-Parkinson's Disease (RC-IRCs/17-18/03, PI)
  • Investigation of Anti-Alzheimer's activity of Protopine derivative for clearing Tau through modulation of HDAC6-Hsp90 interplay and for improving memory via stimulation of RAS-GRF1/ERK pathway (HMRF 15163481, PI)
  • Study of a novel TFEB activator on attenuating Tau pathology in Alzheimer’s disease (GRF/HKBU 12101417, PI)
  • 原阿片碱通过特异性抑制HDAC6用於治疗阿尔兹海默病的实验研究 (NSFC 81773926, PI)

 

成就

  • 中国中药协会首届杰出女中医师奖 (2007)
  • 深圳市虚拟大学园科技项目奖(2011)
  • 香港浸会大学学院优秀学术研究表现奖 (2011-12)
  • 香港浸会大学杰出教学表现奖 (2012-13)
  • 香港浸会大学杰出团队教学表现奖 (2017-18)

     

    出版

    精选期刊论文

    • Song JX, Malampati S, Zeng Y, Durairajan SSK, Yang CB, Tong BC, Iyaswamy A, Shang WB, Sreenivasmurthy SG, Zhu Z, Cheung KH, Lu JH, Tang C, Xu N, Li M*. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2020 Feb;19(2):e13069.doi: 10.1111/acel.13069.
    • Yang C, Zhu Z, Tong BC, Iyaswamy A, Xie WJ, Zhu Y, Sreenivasmurthy SG, Senthilkumar K, Cheung KH, Song JX, Zhang HJ, Li M*. A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38. Redox Biol. 2020 Jan 28:101445. doi: 10.1016/j.redox.2020.101445.
    • Ji F, Sreenivasmurthy SG, Wei J, Shao X, Luan H, Zhu L, Song J, Liu L, Li M*, Cai Z*. Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis. J Hazard Mater. 2019 Oct 15;378:120738.  doi: 10.1016/j.jhazmat.2019.06.015.
    • Yang CB, Cai CZ, Song JX, Tan JQ, Iyaswamy A, Wu MY, Durairajan SSK, Chen LL, Yue ZY, Li M*, Lu JH*. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy, 2017;13(12):2028-2040.  doi:10.1080/15548627.2017.1379633.
    • Chen LL, † Wang YB, † Song JX, † Deng WK, Lu JH, Ma LL, Yang CB, Li M*, Xue Y*. Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy.  Autophagy, 2017;13(11):1969-1980.  doi:10.1080/15548627.2017.1371393.
    • Song JX, YR, Peluso I, Zeng Y, Yu X, Lu JH, Xu Z, Wang MZ, Liu LF, Huang YY, Chen LL, Durairajan SS, Zhang HJ, Zhou B, Zhang HQ, Lu A, Ballabio A, Medina D*, Guo Z*, Li M*. A Novel Curcumin Analog Binds to and Activates TFEB in Vitro and in Vivo Independent of MTOR Inhibition. Autophagy, 2016; 12(8):1372-89.doi: 10.1080/15548627.2016.1179404.
    • Lu JH, He L, Behrends C, Araki M, Araki K, Jun Wang Q, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue ZY*. NRBF2 Regulates Autophagy and Prevents Liver Injury Through Modulating Beclin Atg14L-Linked Phosphatidylinositol-3 Kinase III Activity. Nat. Commun. 2014; 5:3920.   doi: 10.1038/ncomms4920.
    • Song JX, Lu JH, Liu LF, Chen LL, Durairajan SS, Yue Z, Zhang HQ, Li M*. HMGB1 is involved in Autophagy Inhibition Caused by SNCA/alpha-synuclein Overexpression: a Process Modulated by the Natural Autophagy Inducer Corynoxine B. Autophagy. 2014;10(1):144-154. doi: 10.4161/auto.26751.
    • Lu JH, Tan JQ, Durairajan, Liu LF, Zhang ZH, Ma L, Shen HM, Chan HY*, Li M*. Isorhynchophylline, a Natural Alkaloid, Promotes the Degradation of Alpha-synuclein in Neuronal Cells via Inducing Autophagy. Autophagy. 2012; 8(1):98-108. doi: 10.4161/auto.8.1.18313. (Erratum in Autophagy. 2012; 8 (5):864-866.) 
    • Durairajan SSK, Liu LF, Lu JH, Chen LL, Yuan Q, Chung SK, Huang L, Li XS, Huang JD, Li M*. Berberine Ameliorates Beta-amyloid Pathology, Gliosis, and Cognitive Impairment in an Alzheimer's disease Transgenic Mouse Model. Neurobiol Aging. 2012; 33(12): 2903- 2919.  doi: 10.1016/j.neurobiolaging.2012.02.016.