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夏亦荠教授

理学院生物系讲座教授及系主任

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夏亦荠教授

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夏亦荠实验室专注於研究生物如何响应环境变化和调控基因表达。近些年来，愈来愈多的发现表明RNA的修饰，包括RNA加端帽和去端帽，是调控基因表达的重要机制。NAD端帽是原核和真核生物RNA中新发现的一种端帽，但对於NAD端帽的作用机制和生物学功能还所知甚少。

 

夏亦荠实验室近来建立了鉴定NAD端帽和分析其特征的新的方法。正在通过分子生物学、遗传学、生物化学、基因组学等多学科途径来研究模式生物中RNA加端帽和去端帽的机理及其在调控基因表达中的功能。

 

成就

  • 发现和阐述了几个在植物免疫反应中起重要作用的基因和信号分子。
  • 开发了鉴定和分析NAD-capped RNA的新方法。
  • 以首席研究员身份成功申请12项香港及美国政府机构的研究资助，包括美国国家科学基金会 (National Science Foundation)、美国国家卫生院(National Institutes of Health)、10项香港研究资助局的优配研究金(GRF)及 2项香港研究资助局的协作研究金(CRF)。

 

研究成果

  • Li, Y., W. Liu, H. Zhong, H. Zhang H & Y. Xia. “Redox-sensitive bZIP68 plays a role in balancing stress tolerance with growth in Arabidopsis.” Plant Journal 100.4 (2019): 768-783. DOI: 10.1111/tpj.14476
  • Zhang, H., H. Zhong, S. Zhang, X. Shao, M. Ni, Z. Cai, X. Chen & Y. Xia. “NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis.” PNAS 116.24 (2019): 12072-12077.https://doi.org/10.1073/pnas.1903683116
  • Wang, Y., S. Li, Y. Zhao, C. You, B. Le, Z. Gong, B. Mo, Y. Xia & X. Chen. “NAD+-capped RNAs are widespread in the Arabidopsis transcriptome and can probably be translated.” PNAS 116.24 (2019): 12094-12102.https://doi.org/10.1073/pnas.1903682116
  • Zhang, S., H. Zhang, Y. Xia & L. Xiong. “The caseinolytic protease complex component CLPC1 in Arabidopsis maintains proteome and RNA homeostasis in chloroplasts.” BMC Plant Biology 18.1 (2018): 192.
  • Wang, Y., Y. Wu, B. Yu, Z. Yin & Y. Xia. “XLGs interact with AtPUB4 and AtPUB2 and function in multiple plant developmental processes.” Plant Physiology 173.2 (2017): 1235-1246.
  • Guan, G., B. Yan, J. Hua, C. Thieme, H. Zhu, Z. Zhao, F. Kragler, Y. Xia Y & S. Zhang. “PlaMoM: A comprehensive database compiles plant mobile macromolecules.” Nuclear Acid Research 45.D1 (2016): D1021-D1028. DOI: 10.1093/nar/gkw988
  • Zhao, P., P. Liu, J. Shao, C. Li, B. Wang, X. Guo, B. Yan, Y. Xia Y & M. Peng. “Analysis of different strategies adapted by two cassava cultivars in response to drought stress: Ensuring survival or continuing growth.” Journal of Experimental Botany 66.5 (2014): 1477-1488.
  • Liu, P., H. Zhang, H. Wang & Y. Xia Y. “Identification of redox-sensitive cysteines in the Arabidopsis proteome using OxiTRAQ, a quantitative redox proteomics method.” Proteomics 14.6 (2014):750-762.
  • Wang, H., Y. Lu, T. Jiang, H. Berg, C. Li & Y. Xia. “The Arabidopsis U-box/ARM repeat E3 ligase AtPUB4 influences growth and degeneration of tapetal cells and its mutation leads to conditional male sterility.” Plant Journal 74.3 (2013): 511–523.
  • Wang, H., Y. Lu, P. Liu, W. Wen, J. Zhang, X. Ge & Y. Xia. “The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1- dependent autoimmunity of nudt6-2 nudt7.” Plant Journal 73.2 (2012): 262-275.
  • Li, C., J. Shao, Y. Wang, W. Li, D. Guo, B. Yan, Y. Xia & M. Peng. “Analysis of banana transcriptome and global gene expression profiles in banana roots in response to infection by race 1 and tropical race 4 of Fusarium oxysporum f. sp. Cubense.” BMC Genomics 14 (2013): 851.
  • Wang, H., S. Wang, Y. Lu, S. Alvarez, L. Hicks, X. Ge & Y. Xia Y. “Proteomic Analysis of Early-Responsive Redox-Sensitive Proteins in Arabidopsis.” Journal of Proteome Research 11 (2012): 412-424.
  • Lu, Y., C. Li, H. Wang, H. Chen, H. Berg & Y. Xia Y. “AtPPR2, an Arabidopsis pentatricopeptide repeat protein, binds to plastid 23S rRNA and plays an important role in the first mitotic division during gametogenesis and in cell proliferation during embryogenesis.” Plant Journal 67 (2011): 13-25.
  • Xie, Y. D., W. Li, D. Guo, J. Dong, J. Zhang, Y. Fu, D. Ren, M. Peng & Y. Xia. “The Arabidopsis gene SIGMA FACTOR-BINDING PROTEIN 1 plays a role in the salicylate- and jasmonate-mediated defence responses.” Plant, Cell & Environment 33 (2010): 828-839.
  • Zhu, H., G. Li, L. Ding, H. Berg, X. Cui, S. Assmann & Y. Xia. “Arabidopsis extra large G-protein 2 (XLG2) interacts with the Gbeta subunit of heterotrimeric G protein and functions in disease resistance.” Molecular Plant 2 (2009): 513-525.
  • Ge, X., G. Li, S. Wang, H. Zhu, T. Zhu, X. Wang & Y. Xia “AtNUDT7, a negative regulator of basal immunity in Arabidopsis, modulates two distinct defense response pathways and is involved in maintaining redox homeostasis.” Plant Physiology 145 (2007): 204-215.
  • Ge, X., C. Dietrich, M. Matsuno, G. Li, H. Berg, Y. Xia. “An Arabidopsis aspartic protease functions as an anti-cell death component in reproduction and embryogenesis.” EMBO Reports 6 (2005): 282-288.
  • Xia, Y., H. Suzuki, J. Borevitz, J. Blount, Z. Guo, R. Dixon & C. Lamb. “An extracellular aspartic protease in Arabidopsis functions in disease resistance signaling.” EMBO Journal 23 (2004): 980-988.
  • Borevitz, J., Y. Xia, J. Blount, R. Dixon & C. Lamb. “Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis.” Plant Cell 12 (2000): 2383-2394.
  • Delledonne, M., Y. Xia, R. Dixon & C. Lamb. “Nitric oxide functions as a signal in plant disease resistance.” Nature 394 (1998): 585-588.
  • Xia, Y., B. J. Nikolau & P. S. Schnable. “Cloning and characterization of CER2, an Arabidopsis gene that affects cuticular wax accumulation.” Plant Cell 8 (1996): 1291-1304.