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計算醫藥學實驗室

實驗室基於浸大中醫藥學院和理學院（生物系、化學系、數學系和計算機系）的協力合作，創造一個在香港乃至中國最具創新的從中醫藥出發的現代診療和新藥研發基地。實驗室將在生物醫學和化學的基礎上，結合數據科學、資訊科學等先進技術，在浸大打造出一套世界級最完整的現代中醫藥數據資產，成為全球基於中醫藥的現代診療和新藥研發的最權威知識庫。浸大在此研究領域有著非常卓越、扎實的研究基礎。我們將在現有基礎上，聘請科研領軍人才，力爭於三年內，實現包括基於現代分子生物學的「本草綱目新編」中醫知識庫系統和中藥複方協同機制等重大科研成果，同時於大灣區創建第一流的現代中藥新藥創新產業基地，完善從科研到產業的轉化流程，為浸大創造具有國際領先水準的創新產業發展環境。

 

實驗室成員

按此瀏覽實驗室成員名單

 

實驗室遴選委員會

聯席主席：

 

  • 呂愛平教授 (中醫藥學院院長)
  • 劉際明教授 (理學院院長)

 

成員：

 

  • 卞兆祥教授 (中醫藥學)
  • 阮邦志教授 (計算機科學)
  • 翁建霖教授  (生物學)
  • 張宏杰教授 (中醫藥學)
  • 張世平博士 (中醫藥學)

 

項目：

  1. “New Drug Discovery for Aging-associated Neurodegenerative Disorders-Parkinson's Disease”, PI: Prof. Min Li (SCM), Co-Is: Dr. Allen Cheung (BIOL), Dr. Edmond Ma (CHEM), Dr. Ken Leung (CHEM), Dr. King Ho Cheung (SCM), Dr. Chuanbin Yang (External), Dr. Juxian Song (External)
  2. “Detecting the Tipping Points from Inflammation to Tumorigenesis using a Multi-level Network Modeling Approach”, PI: Dr. William Cheung (COMP), Co-Is: Prof. Aiping Lyu (SCM), Prof. Jiming Liu (COMP), Dr. Liang Lan (COMP), Dr. Lu Zhang (COMP), Dr. Daogang Guang (External)
  3. “Specific Differentiation of Dopamine Neurons with Minimal Usage of Growth Factors to Develop Cell Replacement Therapy of Parkinson's Disease”, PI: Prof. Ken Yung (BIOL), Co-Is: Dr. Zhifeng Huang (PHYS), Dr. Stephen Sze (BIOL)
  4. “From Early Detection, Diagnostics to Therapeutics of Alzheimer’s Disease”, PI: Prof. Ricky M. S. Wong (CHEM), Co-Is: Dr. Hung Wing Li (CHEM), Prof. Min Li (SCM), Dr. Ashok Iyaswamy (SCM)
  5. “A High-resolution Global Metagenome Catalog from Uncultured Human Gut Microbiota”, PI: Dr. Lu Zhang (COMP), Co-Is: Prof. Zhaoxiang Bian (SCM), Prof. Xiaodong Fang (External)
  6.  “Chinese Herbal Drug Interaction”, PI: Prof. Zhaoxiang Bian (SCM), Co-I: Prof. Pong Chi Yuen (COMP)
  7.  “Research and development of triptolide-aptamer drug”, PI: Prof. Aiping Lyu (SCM)
  8. “Toward Targeted Therapy in Advanced Pancreatic Cancer: A Smart Triptolide-Nucleolin Aptamer Conjugate”, PI: Prof. Aiping Lyu (SCM)
  9. “Does aberrantly overexpressed CKIP-1 suppress osteoblast-mediated articular bone repair”, PI: Prof. Aiping Lyu (SCM), Co-Is: Dr. Xiaojuan He (External), Prof. Ge Zhang (SCM), Prof. Lingqiang Zhang (External)
  10. “Molecular mechanisms of obesity with Chinese medicine pattern of phlegm-dampness and its changes on hypertension”, PI: Prof. Aiping Lyu (SCM), Co-Is: Dr. Fangfei Li (SCM), Dr. Biao Liu (External), Dr. Bing He (External), Dr. Chao Liang (SCM), Dr. Jin Liu (SCM)
  11. “Onward an emerging paradigm of network medicine: An innovative platform to combinational herbs/compounds-based drug discovery for complex diseases”, PI: Prof. Aiping Lyu (SCM)
  12. “From precision medicine to drug discovery: osteoblast-specific inhibition of Smurf1 activity promotes bone formation in distinctive rats with age-related osteoporosis”, PI: Prof. Ge Zhang (SCM), Co-I: Dr. Chao Liang (SCM)
  13. “Functional Role of Plekho1 within osteoblast in regulating BMP signaling and bone formation during age-related osteoporosis development in both genders: from molecular mechanism to translational therapeutics”, PI: Prof. Ge Zhang (SCM), Co-I: Dr. Baoting Zhang (External)
  14. “Targeting sclerostin to reverse established osteoporosis: Aptamer characterization and evaluation for drug discovery”, PI: Prof. Ge Zhang (SCM), Co-Is: Dr. Chao Liang (SCM), Dr. Yuanyuan Yu (SCM)
  15. “To elucidate the anti-ebola potency of the active leads discovered based on the diversified plants in Lingnan region of China”, PI: Prof. Hongjie Zhang (SCM), Co-Is: Prof. Zhongzhen Zhao (SCM), Dr. Hailong Zhu (SCM)
  16. “Ent-kaurene analogs for control of colorectal carcinoma progression and metastasis”, PI: Prof. Hongjie Zhang (SCM), Co-Is: Dr. Zhizhan Gu (SCM), Prof. Zhongzhen Zhao (SCM)
  17. “Functional analysis of Corynoxine B in promoting autophagy and protecting neurons”, PI: Prof. Min Li (SCM), Co-I: Prof. Long Ma (External)
  18. “Understanding the molecular mechanisms of Corynoxine B in promoting autophagy and neuroprotection: Targeting HMGB1-Beclin 1 interaction”, PI: Prof. Min Li (SCM), Co-Is: Prof. Zhenyu Yue (External), Prof. Yanxiang Zhao (External)
  19. “Study of a novel TFEB activator on attenuating Tau pathology in Alzheimer’s disease”, PI: Prof. Min Li (SCM), Co-Is: Dr. Juxian Song (External), Prof. Joan Zhong Zuo (External)
  20. “Electrophysiological Characterization of the Two-Pore Channel 2”, PI: Dr. King Ho Cheung (SCM)
  21.  “基於大數據和人工智能的中醫藥知識體系分析及自動化藥方生成及推薦”, PI: Prof. Lei Han Tang (PHYS), Co-Is: Prof. Aiping Lyu (SCM), Dr. Liang Tian (PHYS)
  22. “Joint Embedding of Sequential Data and Knowledge Graphs with application to Predictive Analytics in Healthcare”, PI: Dr. William Cheung (COMP), Co-Is: Dr. Benjamin Chin Ming Fung (External), Dr. Jonathan Amias Poon (External)
  23. “A Temporal Tensor Factorization Framework for Phenotyping and Dynamic Patient Representation Learning Using Multi-Modal EHR Data”, PI: Dr. William Cheung (COMP), Co-Is: Dr. Benjamin Chin Ming Fung (External), Dr. Jonathan Amias Poon (External)