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張宏杰教授

部門主任、教授
教學和科研部
中醫藥學院

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張宏杰教授

聯絡

簡歷

張宏杰教授主要從事東南亞天然植物藥用活性成分研究,包括天然小分子化合物的分離、純化、分析、結構解析、結構優化、合成、藥效評估和分子機制研究。他目前已對幾千個植物提取物進行了抗癌、防癌、抗新冠病毒(SARS-CoV)、抗愛滋病(HIV)、抗禽流感病毒、抗Ebola/Marburg病毒、抗菌膜、抗肺結合病和抗瘧疾的生物活性評價,幷已證實多個提取物具有生物活性,幷發現了一些生物活性很強的天然化合物。

張宏杰教授1985年畢業于雲南大學化學系獲學士學位,1988年於中國科學院昆明植物研究所獲植物化學碩士學位,幷于1994年于中科院昆明植物所獲植物化學博士學位,從師于孫漢董院士;1991至2002年,任中科院昆明植物所助理研究員、副研究員和研究員;1999-2011年,在美國伊利諾州立大學芝加哥分校藥學院(College of Pharmacy, University of Illinois at Chicago),歷任博士後(從師Harry H.S. Fong教授)、研究助理教授、研究副教授;2011年12月至今,爲香港浸會大學中醫藥學院副教授、教授。期間作為課題主持人和合作者,張教授參與了有關天然藥物丶傳統草藥(包括中藥)丶有機合成和生物合成等方面的研究項目。

 

 

項目介紹

成就

Patents (26 applications with 20 of them being granted in the US, European and China): 

  • Hongjie Zhang. Anti-cancer agents synthesized based on the miliusane natural products. US Patent, US9,211,333B2, granted on December 15, 2015. 
  • Hongjie Zhang, Yifu Guan. Anticancer miliusane derivatives. US Patent, US9,695,141B2, granted on July 4, 2017. 
  • Hongjie Zhang. Anticancer miliusane lactams. PCT/CN2017/104966. Granted in the US on November 21, 2017 (granted patent No.: US9,822,071B2). 
  • Hongjie Zhang, M.S. Ricky Wong, Lei Guo, Siu Wai Tsang, Kanglun Liu, Tongxin Zhang. Method of use of diterpenoid derivatives as anticancer agents. PCT/CN2017/103320. Granted in the US on October 24, 2017 (granted patent No.: US9,795,589B2). 
  • Hongjie Zhang, D. Doel Soejarto, Harry H.S. Fong. Anticancer maytansinoids with two fused macrocyclic rings. PCT/CN2014/092834. Granted in the US on February 7, 2017 (granted patent No.: US9,562,059B2), in the European on September 19, 2018 (granted patent No.: EP3077402B1), and in China on March 15, 2019  (granted patent No.: ZL201480065649.X).
  • Hongjie Zhang, Siu Wai Tsang. Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of tumorous pathologies. US Patent, US15/849,650, filed on December 20, 2017 (granted patent No.: US9,877,931B2). 
  • Hongjie Zhang. Anticancer and anti-obesity cyclic peptide agents. PCT/CN2013/085301. Granted in the US on November 22, 2016 (granted patent No.: US9,499,586B2), in the European on December 12, 2018 (granted patent No.: EP2909227B1), and in China on April 27, 2018  (granted patent No.: ZL201380048848.5). 
  • Hongjie Zhang. Miliusanes as antiviral agents. Patent filing in the US and China: granted in the US on June 18, 2019 (granted patent No.: US910,323,012B2); China patent: CN2018113063204, filed on November 5, 2018.
  • Hongjie Zhang, Siu Wai Tsang, Zhu Yu. Skin-protection composition containing Dendrobium-based ingredients. PCT/CN2017/107798. Granted in the US on May 1, 2018 (granted patent No.: US9,956,152B2).

 

出版

精選期刊論文

  • Zhao L, Yang W, Huang F, Lu L, Lin C, Huang T, Ning Z, Zhai L, Zhong LLD, Lam W, Yang Z, Zhang X, Cheng C, Han L, Qiu Q, Shang X, Huang R, Xiao H, Ren Z, Chen D, Sun S, El-Nezami H, Lu A, Fang X*, Jia W*, Bian Z*. A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome. J Clin Invest. 2020 Jan 2;130(1):438-450. doi: 10.1172/JCI130976
  • Wong HLX, Qin H, Tsang SW, Zuo X, Che S, Chow CFW, Li X. Xiao HT, Zhao L, Huang T, Lin CY, Kwan HY, Yang T, Longo FM, Lyu A, Bian Z (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications 10(1):1745. doi: 10.1038/s41467-019-09744-3.
  • Chow CFW, Che S, Qin HY, Kwan HY, Bian ZX*, Wong HLX*. From psychology to physicality: How nerve growth factor transduces early life stress into gastrointestinal motility disorders later in life. Cell Cycle. 2019 Aug;18(16):1824-1829. doi: 10.1080/15384101.2019.1637203.
  • Qin HY, Zang KH, Zuo X, Wu XA, Bian ZX. (2019) Quercetin Attenuates Visceral Hypersensitivity and 5-Hydroxytryptamine Availability in Postinflammatory Irritable Bowel Syndrome Rats: Role of Enterochromaffin Cells in the Colon. J Med Food. 2019 Mar 28.
    doi: 10.1089/jmf.2018.4264.
  • Zhao L, Huang Y, Lu L, Yang W, Huang T, Lin Z, Lin CY, Kwan HY, Wong HLX, Chen Y, Sun S, Xie X, Fang X, Yang H, Wang J, Zhu L, Bian Z (2018) Saturated long-chain fatty acid-producing bacteria contributes to enhanced colonic motility in rats. Microbiome 2018;6(1):107.https://doi.org/10.1186/s40168-018-0492-6.
  • Chen GQ, Gong RH, Yang DJ, Zhang G, Lu AP, Yan SC, Lin SH*, Bian ZX*. Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer. Cell Death Dis. 2017 May 11;8(5):e2789.doi: 10.1038/cddis.2017.203.
  • Chung EK, Zhang XJ, Li Z, Zhang HQ, Xu HX, Bian ZX. Neonatal maternal separation enhances central sensitivity to noxious colorectal distention in rat. Brain Res., 2007, 1153: 68-77. 2. doi: 10.1016/j.brainres.2007.03.047
  • Bian ZX, WU TX, Liu L, Miao JX, Wong HF, Song L, Sung JJY. Effectiveness of the Chinese herbal formula TongXieYaoFang for irritable bowel syndrome: a systematic review. J Altern Complement Med., 2006, 12, 401- 407. 3. https://doi.org/10.1089/acm.2006.12.401.
  • Tian XY, Bian ZX, Hu XG, Zhang XJ, Liu L, Zhang HQ. Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway. Brain Res, 2006, 1088:101-8. 4. doi: 10.1016/j.brainres.2006.03.014
  • Bian ZX. Stratification by sex and subgroup is necessary for RCT on IBS. Gut, 2006, 55: 743-4. 5.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856123/