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李敏教授

中醫藥學院副院長(教學)、教學科研部教授
高志明伉儷柏金遜症研究中心主任

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李敏教授

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簡歷

李敏教授，醫學博士。為中醫內科學、中藥神經藥理學、中醫藥治療腦神經退行性疾病專家。目前擔任香港浸會大學中醫藥學院副院長(教學)、中醫與生物醫學雙學位課程主任和高智明伉儷柏金遜症研究中心主任。李教授1985年本科畢業于河南中醫藥大學，1988年碩士畢業于廣州中醫藥大學，2001年在日本東海大學醫學院獲得醫學博士。李教授主要從事神經系統退行性疾病包括柏金遜症和阿氏海默症的中醫臨床治療、中藥藥理研究與新藥研發工作。李教授的研究團隊先後開展了中藥複方治療帕金森病、阿氏海默症的隨機對照雙盲的臨床研究，從中藥中篩選小分子天然自噬誘導劑治療神經退行性疾病的分子作用機制及治療腦神經退行性疾病的中藥新藥研發工作。

 

研究領域：

 

基礎研究：

  • 神經細胞自噬/溶酶體功能異常在老年神經退行性疾病（包括柏金遜症、老年癡呆症）中的發病機制研究；
  • 中藥複方及中藥小分子化合物保護神經細胞的藥效、作用機制及分子靶點研究；
  • 神經退行性疾病相關的代謝組學、蛋白組學的研究。

 

臨床研究：

中藥複方對柏金遜症和阿氏海默症的臨床療效與安全性評價研究。

 

新藥研發：

從中藥複方及中藥小分子化合物研發治療或預防老年神經退行性疾病（帕金森病和阿氏海默症）的中藥新藥和中藥保健品。

 

 

主持的科研項目 (最近三年)

 

  • Evaluating the anti-Alzheimer’s disease efficacy of Caudatin, isolated from Chinese medicine herb Qingyangshen, on AD mice model (HMRF 17182541, PI)
  • Neuroprotective Effect of Chinese medicine NeuroDefend in Improving Memory Dysfunction and Alleviating AD Pathology (GDSSIL 84-506/2019, PI)
  • Study of Chinese Medicine Protopine on Attenuating Tau Pathology in Alzheimer's Disease: The Roles of Histone Deacetylase 6 (GRF/HKBU12100618, PI)
  • New Drug Discovery for Aging-associated Neurodegenerative Disorders-Parkinson's Disease (RC-IRCs/17-18/03, PI)
  • Investigation of Anti-Alzheimer's activity of Protopine derivative for clearing Tau through modulation of HDAC6-Hsp90 interplay and for improving memory via stimulation of RAS-GRF1/ERK pathway (HMRF 15163481, PI)
  • Study of a novel TFEB activator on attenuating Tau pathology in Alzheimer’s disease (GRF/HKBU 12101417, PI)
  • 原阿片碱通過特異性抑制HDAC6用於治療阿爾茲海默病的實驗研究 (NSFC 81773926, PI)

 

成就

  • 中國中藥協會首屆傑出女中醫師獎 (2007)
  • 深圳市虛擬大學園科技項目獎(2011)
  • 香港浸會大學學院優秀學術研究表現獎 (2011-12)
  • 香港浸會大學傑出教學表現獎 (2012-13)
  • 香港浸會大學傑出團隊教學表現獎 (2017-18)

     

    出版

    精選期刊論文

    • Song JX, Malampati S, Zeng Y, Durairajan SSK, Yang CB, Tong BC, Iyaswamy A, Shang WB, Sreenivasmurthy SG, Zhu Z, Cheung KH, Lu JH, Tang C, Xu N, Li M*. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2020 Feb;19(2):e13069.doi: 10.1111/acel.13069.
    • Yang C, Zhu Z, Tong BC, Iyaswamy A, Xie WJ, Zhu Y, Sreenivasmurthy SG, Senthilkumar K, Cheung KH, Song JX, Zhang HJ, Li M*. A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38. Redox Biol. 2020 Jan 28:101445. doi: 10.1016/j.redox.2020.101445.
    • Ji F, Sreenivasmurthy SG, Wei J, Shao X, Luan H, Zhu L, Song J, Liu L, Li M*, Cai Z*. Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis. J Hazard Mater. 2019 Oct 15;378:120738.  doi: 10.1016/j.jhazmat.2019.06.015.
    • Yang CB, Cai CZ, Song JX, Tan JQ, Iyaswamy A, Wu MY, Durairajan SSK, Chen LL, Yue ZY, Li M*, Lu JH*. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy, 2017;13(12):2028-2040.  doi:10.1080/15548627.2017.1379633.
    • Chen LL, † Wang YB, † Song JX, † Deng WK, Lu JH, Ma LL, Yang CB, Li M*, Xue Y*. Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy.  Autophagy, 2017;13(11):1969-1980.  doi:10.1080/15548627.2017.1371393.
    • Song JX, YR, Peluso I, Zeng Y, Yu X, Lu JH, Xu Z, Wang MZ, Liu LF, Huang YY, Chen LL, Durairajan SS, Zhang HJ, Zhou B, Zhang HQ, Lu A, Ballabio A, Medina D*, Guo Z*, Li M*. A Novel Curcumin Analog Binds to and Activates TFEB in Vitro and in Vivo Independent of MTOR Inhibition. Autophagy, 2016; 12(8):1372-89.doi: 10.1080/15548627.2016.1179404.
    • Lu JH, He L, Behrends C, Araki M, Araki K, Jun Wang Q, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue ZY*. NRBF2 Regulates Autophagy and Prevents Liver Injury Through Modulating Beclin Atg14L-Linked Phosphatidylinositol-3 Kinase III Activity. Nat. Commun. 2014; 5:3920.   doi: 10.1038/ncomms4920.
    • Song JX, Lu JH, Liu LF, Chen LL, Durairajan SS, Yue Z, Zhang HQ, Li M*. HMGB1 is involved in Autophagy Inhibition Caused by SNCA/alpha-synuclein Overexpression: a Process Modulated by the Natural Autophagy Inducer Corynoxine B. Autophagy. 2014;10(1):144-154. doi: 10.4161/auto.26751.
    • Lu JH, Tan JQ, Durairajan, Liu LF, Zhang ZH, Ma L, Shen HM, Chan HY*, Li M*. Isorhynchophylline, a Natural Alkaloid, Promotes the Degradation of Alpha-synuclein in Neuronal Cells via Inducing Autophagy. Autophagy. 2012; 8(1):98-108. doi: 10.4161/auto.8.1.18313. (Erratum in Autophagy. 2012; 8 (5):864-866.) 
    • Durairajan SSK, Liu LF, Lu JH, Chen LL, Yuan Q, Chung SK, Huang L, Li XS, Huang JD, Li M*. Berberine Ameliorates Beta-amyloid Pathology, Gliosis, and Cognitive Impairment in an Alzheimer's disease Transgenic Mouse Model. Neurobiol Aging. 2012; 33(12): 2903- 2919.  doi: 10.1016/j.neurobiolaging.2012.02.016.