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夏亦薺教授

理學院生物系教授

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夏亦薺教授

聯絡

簡歷

夏亦薺實驗室專注於研究生物如何響應環境變化和調控基因表達。近些年來,愈來愈多的發現表明RNA的修飾,包括RNA加端帽和去端帽,是調控基因表達的重要機製。NAD端帽是原核和真核生物RNA中新發現的一種端帽,但對於NAD端帽的作用機製和生物學功能還所知甚少。

 

夏亦薺實驗室近來建立了鑒定NAD端帽和分析其特征的新的方法。正在通過分子生物學、遺傳學、生物化學、基因組學等多學科途徑來研究模式生物中RNA加端帽和去端帽的機理及其在調控基因表達中的功能。

 

成就

  • 發現和闡述了幾個在植物免疫反應中起重要作用的基因和信號分子。
  • 開發了鑒定和分析NAD-capped RNA的新方法。
  • 以首席研究員身份成功申請12項香港及美國政府機構的研究資助,包括美國國家科學基金會 (National Science Foundation)、美國國家衛生院(National Institutes of Health)、10項香港研究資助局的優配研究金(GRF)及 2項香港研究資助局的協作研究金(CRF)。

 

研究成果

  • Li, Y., W. Liu, H. Zhong, H. Zhang H & Y. Xia. “Redox-sensitive bZIP68 plays a role in balancing stress tolerance with growth in Arabidopsis.” Plant Journal 100.4 (2019): 768-783. DOI: 10.1111/tpj.14476
  • Zhang, H., H. Zhong, S. Zhang, X. Shao, M. Ni, Z. Cai, X. Chen & Y. Xia. “NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis.” PNAS 116.24 (2019): 12072-12077.https://doi.org/10.1073/pnas.1903683116
  • Wang, Y., S. Li, Y. Zhao, C. You, B. Le, Z. Gong, B. Mo, Y. Xia & X. Chen. “NAD+-capped RNAs are widespread in the Arabidopsis transcriptome and can probably be translated.” PNAS 116.24 (2019): 12094-12102.https://doi.org/10.1073/pnas.1903682116
  • Zhang, S., H. Zhang, Y. Xia & L. Xiong. “The caseinolytic protease complex component CLPC1 in Arabidopsis maintains proteome and RNA homeostasis in chloroplasts.” BMC Plant Biology 18.1 (2018): 192.
  • Wang, Y., Y. Wu, B. Yu, Z. Yin & Y. Xia. “XLGs interact with AtPUB4 and AtPUB2 and function in multiple plant developmental processes.” Plant Physiology 173.2 (2017): 1235-1246.
  • Guan, G., B. Yan, J. Hua, C. Thieme, H. Zhu, Z. Zhao, F. Kragler, Y. Xia Y & S. Zhang. “PlaMoM: A comprehensive database compiles plant mobile macromolecules.” Nuclear Acid Research 45.D1 (2016): D1021-D1028. DOI: 10.1093/nar/gkw988
  • Zhao, P., P. Liu, J. Shao, C. Li, B. Wang, X. Guo, B. Yan, Y. Xia Y & M. Peng. “Analysis of different strategies adapted by two cassava cultivars in response to drought stress: Ensuring survival or continuing growth.” Journal of Experimental Botany 66.5 (2014): 1477-1488.
  • Liu, P., H. Zhang, H. Wang & Y. Xia Y. “Identification of redox-sensitive cysteines in the Arabidopsis proteome using OxiTRAQ, a quantitative redox proteomics method.” Proteomics 14.6 (2014):750-762.
  • Wang, H., Y. Lu, T. Jiang, H. Berg, C. Li & Y. Xia. “The Arabidopsis U-box/ARM repeat E3 ligase AtPUB4 influences growth and degeneration of tapetal cells and its mutation leads to conditional male sterility.” Plant Journal 74.3 (2013): 511–523.
  • Wang, H., Y. Lu, P. Liu, W. Wen, J. Zhang, X. Ge & Y. Xia. “The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1- dependent autoimmunity of nudt6-2 nudt7.” Plant Journal 73.2 (2012): 262-275.
  • Li, C., J. Shao, Y. Wang, W. Li, D. Guo, B. Yan, Y. Xia & M. Peng. “Analysis of banana transcriptome and global gene expression profiles in banana roots in response to infection by race 1 and tropical race 4 of Fusarium oxysporum f. sp. Cubense.” BMC Genomics 14 (2013): 851.
  • Wang, H., S. Wang, Y. Lu, S. Alvarez, L. Hicks, X. Ge & Y. Xia Y. “Proteomic Analysis of Early-Responsive Redox-Sensitive Proteins in Arabidopsis.” Journal of Proteome Research 11 (2012): 412-424.
  • Lu, Y., C. Li, H. Wang, H. Chen, H. Berg & Y. Xia Y. “AtPPR2, an Arabidopsis pentatricopeptide repeat protein, binds to plastid 23S rRNA and plays an important role in the first mitotic division during gametogenesis and in cell proliferation during embryogenesis.” Plant Journal 67 (2011): 13-25.
  • Xie, Y. D., W. Li, D. Guo, J. Dong, J. Zhang, Y. Fu, D. Ren, M. Peng & Y. Xia. “The Arabidopsis gene SIGMA FACTOR-BINDING PROTEIN 1 plays a role in the salicylate- and jasmonate-mediated defence responses.” Plant, Cell & Environment 33 (2010): 828-839.
  • Zhu, H., G. Li, L. Ding, H. Berg, X. Cui, S. Assmann & Y. Xia. “Arabidopsis extra large G-protein 2 (XLG2) interacts with the Gbeta subunit of heterotrimeric G protein and functions in disease resistance.” Molecular Plant 2 (2009): 513-525.
  • Ge, X., G. Li, S. Wang, H. Zhu, T. Zhu, X. Wang & Y. Xia “AtNUDT7, a negative regulator of basal immunity in Arabidopsis, modulates two distinct defense response pathways and is involved in maintaining redox homeostasis.” Plant Physiology 145 (2007): 204-215.
  • Ge, X., C. Dietrich, M. Matsuno, G. Li, H. Berg, Y. Xia. “An Arabidopsis aspartic protease functions as an anti-cell death component in reproduction and embryogenesis.” EMBO Reports 6 (2005): 282-288.
  • Xia, Y., H. Suzuki, J. Borevitz, J. Blount, Z. Guo, R. Dixon & C. Lamb. “An extracellular aspartic protease in Arabidopsis functions in disease resistance signaling.” EMBO Journal 23 (2004): 980-988.
  • Borevitz, J., Y. Xia, J. Blount, R. Dixon & C. Lamb. “Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis.” Plant Cell 12 (2000): 2383-2394.
  • Delledonne, M., Y. Xia, R. Dixon & C. Lamb. “Nitric oxide functions as a signal in plant disease resistance.” Nature 394 (1998): 585-588.
  • Xia, Y., B. J. Nikolau & P. S. Schnable. “Cloning and characterization of CER2, an Arabidopsis gene that affects cuticular wax accumulation.” Plant Cell 8 (1996): 1291-1304.