Transformative development of multimodal functional metabolomics strategies for translational medicine innovation
Project Description
Professor Lyu Haitao’s group primarily focuses on the methodological development and translational application of functional metabolomics within the interdisciplinary fields of life and health sciences. The following key points highlight our unique research findings:
- Definition and development of innovative methods and strategies in functional metabolomics, including precision-modification metabolomics (PMM) and spatial-temporal operative real metabolomics (STORM).
- Elucidation of a new regulatory mechanism for siderophore biosynthesis and its role in biofilm formation in pathogenic Escherichia coli at a functional metabolism level. This work proposes a novel strategy to mitigate the harmful effects of biofilms by targeting functional metabolites, which contribute significantly to drug resistance, environmental pollution, and food contamination.
- Identification of novel metabolite biomarkers and drug targets that can enhance the diagnosis and treatment of pancreatic cancer, hepatitis, and inflammatory bowel diseases (IBDs), as well as the characterisation of new metabolic targets for identifying druggable natural products
Currently, Professor Lyu's group is further exploring next-generation functional metabolomics (STORM+) to promote interdisciplinary applications in life and health sciences through the discovery of poly-functional metabolites.
Based on our research findings, we have successfully secured several national competitive grants and international research awards, including the National Key Research and Development Project, the National Natural Science Foundation of China Grant, and the Agilent Tech Global ACT-UR Award. Additionally, we have published 20 peer-reviewed papers in prestigious journals, such as Acta Pharmaceutica Sinica B, Pharmacological Research, Cell Reports Methods, and Pharmacology & Therapeutics, among others.
Collectively, our innovative work in functional metabolomics for translational medicine attempts to address the challenging unmet clinical needs. This innovative approach aims to establish a new research paradigm and scientific foundation for the precise diagnosis and treatment of many complex diseases. It is anticipated to facilitate the development of clinical diagnostic kits and new therapies in the near future, thereby significantly improving population health from a functional metabolomic standpoint.
Project Investigator
Professor LYU Haitao (School of Chinese Medicine)
Project Collaborators
- Shanghai Jiao Tong University, China
- Xi'an Jiaotong University, China
Funding/Award
- Ministry of Science and Technology, People's Republic of China - National Key Research & Development Project
- Ministry of Science and Technology, People's Republic of China - National Center for Translational Medicine Key Project
- US Agilent Tech Foundation - Agilent Core Technology-University Research Award
Publications
- Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan administration to attenuate the colitis through AhR signaling activation. Acta Pharmaceutica Sinica B, 2024, accepted.
- A cross-disease, pleiotropy-driven approach for therapeutic target prioritization and evaluation. Cell Reports Methods, 2024, 4(4), 100757. DOI: 10.1016/j.crmeth.2024.100757
- Functional metabolomics revealed the dual-activation of cAMP-AMP axis is a novel therapeutic target of pancreatic cancer. Pharmacological Research, 2023, 187, 106554. DOI: 10.1016/j.phrs.2022.106554
- Functional metabolomics defined metabolic-characteristics of chronic hepatitis that is significantly differentiated from acute hepatitis. Pharmacological Research, 2022, 180, 106248. DOI: 10.1016/j.phrs.2022.106248
