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Health and Drug Discovery

CMP

 

This cluster seeks to transform health and well-being. Researchers at HKBU break barriers by integrating cutting-edge sciences, like Chinese medicine philosophy, chemical biology, data analytics, and environmental, physical & social sciences. Aiming to revolutionise preventive measures, diagnosis, and therapeutic treatments for human diseases, HKBU is ready for an exhilarating journey to enhance health, ignite prosperity, and change lives.

Research Highlights

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NAD capping of RNAs: mechanisms and functions 

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Stiffness in nonlinear brain connectome: Identifying effective strategies for modulating neurocognition and treating neuropsychiatric disorders

 

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From target understandings of sclerostin to therapeutic aptamer drug discovery

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Development of a new therapeutic inhibitor for nasopharyngeal carcinoma 

 

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Resource utilisation and environmental impact mitigation of plastic waste

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Transformative development of multimodal functional metabolomics strategies for translational medicine innovation

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New regulatory mechanism for insulin resistance and therapeutic target for age-related diabetes 

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Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis 

 

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New regulatory mechanism of satiety and therapeutic target for obesity 

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Application of polysaccharide as chemical marker in quality control of saccharide-dominant Chinese medicines: cordyceps sinensis, a case study

 

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Impairment of autophagy-lysosomal pathway in Parkinson's disease: Novel roles of HMGB1-TFEB interplay and therapeutic implication of Chinese medicine compounds 

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Rapid antimicrobial susceptibility testing for precision therapy of bacterial infection 

 

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Elucidating the role of TLR4/STAT3 signaling in the antimelanoma effects of atractylenolide II

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Exploration of Justicia plants as innovative antimicrobial solutions against highly pathogenic avian influenza virus (HPAIV) for veterinary and human health

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CDD-2101: Novel Chinese medicine for the treatment of chronic constipation authorized by U.S. FDA for clinical trial

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CDD-2103: A self-developed Chinese medicine for the treatment of Ulcerative Colitis approved by National Medical Products Administration for clinical trial 

 

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CDD-2107: Hong Kong's first botanical drug granted FDA orphan drug designation for the treatment of BAG3-related myofibrillar myopathy (Bag3opathy)

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Elevating chronic disease care: Communication interventions to enhance symptom management in patients with irritable bowel disease

 

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Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis

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Statistics did not prove that the Huanan Seafood Wholesale Market was the early epicentre of the COVID-19 pandemic

 

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New cell entry mechanism of SARS-CoV-2 and therapeutic target for COVID-19

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Molecular understanding and drug discovery on the complex interaction between obesity and cancer guided by holistic view of TCM

Cluster Research Units